Nanopore Bioelectronics for Next Generation Proteomics
SBIR Opportunity Analysis
DARPA, through the DoD SBIR program, is seeking a next-generation single-molecule sensing and sequencing platform for biomolecules, especially proteins, to improve rapid identification of unknown biological threats and other protein-based signatures. The work centers on nanopore-based technologies, including novel sample preparation, engineered nanopores and motor proteins, custom microsystem interfaces, and high-accuracy sequence-calling algorithms. Phase I is focused on proving technical feasibility and showing a path to high speed, accuracy, chemical diversity, stability, throughput, and eventual scalability, with later phases aimed at robustness, reproducibility, and transition to commercial or government use. The topic is DPA26BZ02-NV006 under solicitation 26.BZ, and the application due date is June 24, 2026 at 4:00 PM UTC.