Nanopore Bioelectronics for Next Generation Proteomics
SBIR Opportunity Analysis
The Department of Defense, through the Defense Advanced Research Projects Agency, is seeking proposals under SBIR topic DPA26BZ02-NV006 to develop a next-generation single-molecule sensing and sequencing platform for proteins. Performers must design nanopore-based technologies, novel sample preparation methods, engineered protein-based motors, and machine learning models for signal deconvolution to achieve rapid, real-time identification of unknown biomolecules. Phase I work requires establishing technical feasibility and delivering fixed payable milestones, including a kickoff report, an interim prototype performance report, a chemistry validation demonstration, and a final prototype system report. The ultimate goal is to mature this technology in Phase II and transition it in Phase III for dual-use applications such as field detection of biothreats and commercial medical diagnostics. Proposals must be submitted by June 24, 2026, at 4:00 PM Eastern Time.