Scalable Biomanufacturing of Sequence-Defined Aramid Copolymers
ID: OSD25D-002Type: BOTH
Overview

Topic

Scalable Biomanufacturing of Sequence-Defined Aramid Copolymers

Agency

Agency: DODBranch: OSD

Program

Type: STTRPhase: BOTH

Topic Link

https://www.dodsbirsttr.mil/topics-app/

Additional Information

https://www.dodsbirsttr.mil/topics-app/
Timeline
    Description

    The Department of Defense (DOD) is seeking innovative solutions through the Small Business Innovation Research (SBIR) program for the development of scalable biomanufacturing processes for sequence-defined aramid copolymers, specifically targeting high-performance materials used in aerospace and military applications. The objective is to create reliable and cost-effective cellular or cell-free processes that utilize genomically recoded organisms to incorporate non-canonical amino acids, thereby synthesizing aramid copolymers with controlled monomer sequences to enhance material properties. These advanced materials are crucial for applications requiring high tensile strength and durability, such as personal armor and aerospace composites. The solicitation is set to open on May 28, 2025, with proposals due by June 25, 2025, and further details can be found at the DOD SBIR/STTR website.

    Files
    Title
    Posted
    PDF.html
    Similar Opportunities
    Novel Sampling Tickets for Surface Enhanced Raman Spectroscopy (SERS) of Chemical and Biological (CB) Threat Materials -
    DOD
    The Department of Defense (DOD) is seeking innovative solutions through the Small Business Innovation Research (SBIR) program for the development of novel sampling tickets designed for Surface Enhanced Raman Spectroscopy (SERS) to detect chemical and biological (CB) threat materials. The primary objective is to create physically semi-porous, flexible coupons that enhance the sensitivity and selectivity of existing handheld Raman detectors, which currently face challenges in identifying trace amounts of hazardous substances from various surfaces in operational environments. This initiative is crucial for improving the capabilities of military units in detecting a range of threats, including nerve agents and toxins, thereby enhancing battlefield safety and operational effectiveness. Interested parties should note that the solicitation number is CBD254-006, with a release date of September 3, 2025, and proposals are due by December 31, 2025. For more information, please visit the DOD SBIR website at https://www.dodsbirsttr.mil/topics-app/.
    Far Forward Manufacturing of CBRN Sensors -
    DOD
    The Department of Defense (DoD) is seeking proposals for the Far Forward Manufacturing (FFM) of Chemical, Biological, Radiological, and Nuclear (CBRN) sensors, as outlined in solicitation number CBD254-008. The objective is to accelerate the production of compact and economical CBRN sensors that require minimal logistical footprints, enabling real-time threat detection for warfighters while reducing reliance on complex supply chains through advanced manufacturing techniques such as 3D printing and biomanufacturing. This initiative is critical for ensuring force readiness and adaptability in modern warfare, with potential dual-use applications in commercial sectors like clinical diagnostics and environmental sensing. Interested parties should note that Phase I proposals are due by December 31, 2025, with potential funding of up to $500,000 available for successful Phase II performers who secure additional non-SBIR/STTR funding.
    Shelf-Stable Nucleic Acid Synthesis Reagents for Field-Deployable Diagnostics -
    DOD
    The Department of Defense's Chemical and Biological Defense Program (CBDP) is seeking innovative solutions for the development of shelf-stable nucleic acid synthesis reagents aimed at enhancing rapid diagnostic capabilities in expeditionary environments. The primary objective is to create reagents that remain effective at room temperature, function across a temperature range of -20°C to 55°C, and possess a shelf life of at least 12 months, while also improving the yield of synthesized nucleic acids. This initiative is critical for enabling the rapid development and deployment of diagnostic assays in remote locations, addressing the limitations of current technologies that require cold chain storage and have short shelf lives. Interested parties should note that the solicitation is set to open on December 10, 2025, with applications due by December 31, 2025, and further details can be found at the provided source link: https://www.dodsbirsttr.mil/topics-app/.
    Complex Geometries for Extended Wear Respirators Towards Regenerable Particulate Matter Protection -
    DOD
    The Department of Defense is seeking innovative solutions through the SBIR program to develop a rugged, 3D-printable, PFAS-free particulate filtration impactor system for extended-wear respirators in military operational environments. The objective is to create a regenerable filtration system that effectively reduces particulate matter (PM10 and PM2.5) exposure, addressing current limitations such as discomfort, clogging, and single-use constraints, while ensuring minimal breathing resistance during aerobic activities. This technology is crucial for protecting warfighters from cardiovascular and pulmonary diseases associated with high airborne particulate levels. Interested parties should note that the solicitation is set to open on December 10, 2025, with applications due by December 31, 2025, and further details can be found at the provided source link.
    Integrated Deployable Microsensors for Chemical Detection -
    DOD
    The Department of Defense (DoD) is seeking proposals for the development of Integrated Deployable Microsensors for Chemical Detection, aimed at providing early warning of chemical threats. The objective is to create a low size, weight, power, and cost (SWaP-C) microsensor capable of detecting chemical weapons agents and pharmaceutical-based agents in vapor and aerosol forms within a critical timeframe of 10 minutes. This technology is crucial for enhancing rapid response and decision-making in both military and civilian contexts, particularly for first responders in environmental detection and health monitoring. Proposals are due by December 31, 2025, with the opportunity opening on December 10, 2025, and further details can be found at the DoD SBIR website.
    Unbiased Behavioral Discovery Platforms -
    DOD
    The Department of Defense (DoD), through the Defense Advanced Research Projects Agency (DARPA), is seeking innovative solutions for the development of unbiased behavioral discovery platforms aimed at enhancing the detection and development of medical countermeasures against chemical and biological threats. The primary objective is to create automated systems capable of quantifying novel animal behaviors in preclinical models with greater sensitivity and specificity than current methodologies, while minimizing variability and ethical concerns associated with traditional animal testing. This initiative is critical for accelerating the identification of effective medical countermeasures and improving defense health capabilities. Interested parties should note that the opportunity is part of the Small Business Innovation Research (SBIR) program, with a release date of September 3, 2025, and applications due by December 31, 2025. For more information, visit the official solicitation page at https://www.dodsbirsttr.mil/topics-app/.
    OPEN TOPIC - Tactical CB Visualization -
    DOD
    The Department of Defense (DOD) is seeking innovative solutions through the Small Business Innovation Research (SBIR) program to enhance situational awareness and decision support for Warfighters operating in Chemical and Biological (CB) contested environments. The objective is to develop tactical visualization tools that efficiently integrate, visualize, and communicate tactical data, with a focus on Human-Machine Interface concepts and significant advantages in size, weight, and power (SWAP) demands. Proposed technologies may include augmented reality, sensor visualization, or unique end-user devices, and must comply with Integrated Sensor Architecture (ISA) standards and the Tactical Assault Kit (TAK) Software Development Kit (SDK). The opportunity is currently in the pre-release phase, with an open date of December 10, 2025, and a close date of December 31, 2025, for applications. Interested parties can find more information and submit proposals through the DOD SBIR website.
    Microphysiological systems to Assess Pretreatment Immunogenicity and Efficacy (MAGPIE) -
    DOD
    The Defense Threat Reduction Agency (DTRA) is seeking proposals for the development of Microphysiological systems to Assess Pretreatment Immunogenicity and Efficacy (MAGPIE), specifically immune microphysiological systems (iMPS) aimed at evaluating vaccines against high-consequence pathogens. The primary objective is to create iMPS that can replicate known vaccine responses, differentiate vaccine efficacy, and predict the immunogenicity of novel vaccine constructs, thereby addressing the limitations of traditional vaccine development models. This initiative is crucial for enhancing warfighter readiness by facilitating accelerated vaccine development and reducing reliance on traditional animal models. Interested parties should note that the solicitation is set to open on December 10, 2025, with applications due by December 31, 2025, and further details can be found at the DOD SBIR/STTR website.
    Novel Technologies for CWMD and Related Threats - Open Topic -
    DOD
    The Defense Threat Reduction Agency (DTRA) is seeking innovative solutions through its Small Business Innovation Research (SBIR) program to develop novel technologies for detecting radiological and nuclear threats without the use of specialized sensors. The objective is to utilize signals from existing general-purpose military hardware, commercially available devices, and public data sources to enhance the detection capabilities for weapons of mass destruction (WMD). This initiative is crucial for overcoming the challenges associated with the high costs and lengthy timelines of developing new military hardware for WMD detection. The project is structured in three phases: Phase I focuses on identifying feasible use cases and developing a course of action; Phase II involves building and testing a model or prototype; and Phase III aims to refine the technology for broader dual-use applications in defense, government, and commercial sectors. The solicitation is currently in pre-release status, with an open date set for December 10, 2025, and a close date of December 31, 2025. Interested parties can find more information and submit proposals through the DOD SBIR website.
    Acoustic-based UAS Rainbow Oscillation Refraction Architecture (AURORA) -
    DOD
    The Department of Defense, specifically the Special Operations Command (SOCOM), is seeking innovative research and development proposals for the Acoustic-based UAS Rainbow Oscillation Refraction Architecture (AURORA) under the SBIR program. The objective is to create an acoustic-based communication system that enables small uncrewed aerial systems (sUAS) within a swarm to communicate and determine their relative positions using sound generated by their propellers as a carrier wave. This technology is crucial for military applications where multiple drones operate in close proximity without relying on GPS or radio frequencies, enhancing their operational effectiveness and safety. Interested parties should prepare to submit their proposals by December 31, 2025, with the feasibility study phase (Phase I) focusing on system design options and achievable data rates, followed by prototype development in Phase II. For more details, visit the solicitation agency's website at https://www.dodsbirsttr.mil/topics-app/.