The Department of Defense, specifically the United States Air Force, is seeking proposals for the SBIR topic titled "REGION (Research and Engineering for Global operations in low IONosphere)," aimed at developing technologies for operations in the Stratosphere, Mesosphere, and Thermosphere. The objective is to explore and prototype systems capable of long-endurance sensing in the near-space environment, which is critical for enhancing military capabilities that bridge air and space domains. This initiative is particularly important as it addresses the need for innovative solutions that can operate seamlessly between these domains, providing new operational capabilities for combatant commanders. Proposals are due by June 25, 2025, and interested parties can find more information and submit their applications through the SBIR website at https://www.sbir.gov/topics/12092.