The Department of Defense (DOD) is seeking proposals for a hydrogel-based drug delivery product for traumatic brain injury (TBI). The objective is to develop a biodegradable hydrogel system that can seal open-skull fractures or penetrating TBIs and release hemostatic agents, antimicrobials, and drugs to prevent brain swelling and herniation. The product should be easily administered by combat medics and have the potential for self or buddy-administration in austere settings. The proposal should include proof-of-concept for a hydrogel-based drug delivery platform in Phase I and pre-clinical in vivo exploratory studies in Phase II. The performer should also develop a transition plan for operational capability and demonstrate the potential for civilian use. The performer's transition plan should include a clinical development plan, product development plan, and a business case for commercialization. The deadline for proposal submission is June 12, 2024. For more information, visit the DOD SBIR website.