The Department of Health and Human Services, specifically the National Institutes of Health, is seeking proposals for tools to support decentralized clinical trials for substance use disorder (SUD). Traditional SUD clinical trials require in-person visits, which can limit participation and retention due to factors such as travel time, stigma, and childcare responsibilities. Decentralized clinical trials (DCT) offer a solution by utilizing telehealth visits, remote monitoring, and local medication dispensing. However, there are gaps in the technology needed for DCT, such as wearable sensors for physiological measurement and a comprehensive system for secure data sharing and communication. The goal of this solicitation is to develop tools for DCT that increase participation, diversity, and retention in SUD clinical trials. The research and development areas of interest include wearable devices for drug measurement, socially acceptable devices for SUD trials, software solutions for data handling, and systems that can operate in low-bandwidth or rural areas. The Small Business Innovation Research (SBIR) program offers Phase I, Fast Track, and Direct-to-Phase II funding opportunities for eligible applicants. The application due date for this solicitation is March 14, 2024. For more information, visit the SBIR topic link (https://www.sbir.gov/node/2486901) or the solicitation agency URL (https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-25-052.html).