The Department of Defense, specifically the United States Air Force (USAF), is seeking proposals for the SBIR topic titled "REGION (Research and Engineering for Global operations in low IONosphere)," aimed at developing systems capable of operating seamlessly between the air and space domains at altitudes ranging from 30 km to 100 km. The objective is to explore innovative concepts and technologies that enhance capabilities in the near-space region, focusing on long endurance sensing and operational effectiveness, particularly in Intelligence, Surveillance, and Reconnaissance (ISR) and material transport. This initiative is critical as it aims to leverage advancements in technology to provide new operational capabilities that have not been fully explored, with a focus on rapid prototyping and integration into the DAF's digital infrastructure. Proposals are due by June 25, 2025, with the opportunity to transition technologies into commercial applications in Phase III. Interested parties can find more information and submit proposals through the official SBIR website at https://www.dodsbirsttr.mil/topics-app/.