Development of Organoid Screening Tool for High-Throughput Compound Screening to Be Used in Military-Relevant Exposures

The Department of Defense (DOD) is seeking proposals for the Small Business Innovation Research (SBIR) program focused on the development of an advanced organoid screening tool for high-throughput compound screening related to military-relevant exposures. The objective is to create a high-throughput platform utilizing human-derived organoids to predict compound exposure, toxicity, and efficacy, thereby enhancing drug discovery processes for trauma-related injuries such as traumatic brain injuries. This innovative approach aims to replace traditional 2D cell cultures and animal models with a more accurate and efficient method for evaluating therapeutic compounds, ultimately accelerating the drug development timeline. The solicitation is set to open on January 8, 2025, with applications due by February 5, 2025. Interested parties can find more information and submit proposals through the DOD SBIR/STTR website.