Development of Bacteriophage for Treatment of Mycobacterial Infections
ID: NIH/NIAID 131Type: BOTH
Overview

Topic

Development of Bacteriophage for Treatment of Mycobacterial Infections

Agency

Department of Health and Human ServicesNational Institutes of Health

Program

Type: SBIRPhase: BOTHYear: 2023

Topic Link

https://www.sbir.gov/node/2451739

Additional Information

https://sam.gov/opp/aa72581c848947f0b61c15062e604862/view
Timeline
  1. 1
    Release Aug 25, 2023 12:00 AM
  2. 2
    Open Aug 25, 2023 12:00 AM
  3. 3
    Next Submission Due Nov 14, 2023 12:00 AM
  4. 4
    Close Nov 14, 2023 12:00 AM
Description

The Department of Health and Human Services, specifically the National Institutes of Health (NIH) and The Centers for Disease Control and Prevention (CDC), are seeking proposals for the development of bacteriophage for the treatment of mycobacterial infections. The goal is to address the urgent need for new therapeutics for pulmonary diseases caused by mycobacteria, including tuberculosis and pulmonary infections caused by non-tuberculous mycobacterium species. The solicitation is open to Fast-Track proposals, with a total of 2-3 anticipated awards. The budget for Phase I is $300,000 for up to one year, and for Phase II is $1,500,000 for up to 3 years. The deadline for proposal submission is November 14, 2023. For more information, visit the SBIR topic link here and the solicitation agency URL here.

Files
No associated files provided.
Similar Opportunities
DOD SBIR 24.4 Annual - Sample Collection and Processing Methods to Support Battlefield Wound Infection Diagnostics (Direct to Phase II)
Active
Department of Defense
The Department of Defense (DOD) is seeking proposals for a Small Business Innovation Research (SBIR) program focused on the topic of "Sample Collection and Processing Methods to Support Battlefield Wound Infection Diagnostics (Direct to Phase II)". The Defense Health Agency is the branch responsible for this topic. The objective is to develop a simple-to-use sample collection and processing method capable of preparing an adequate specimen for the identification and accurate detection of specific fungal and/or bacterial species commonly associated with complex battlefield wound infections. The technology should be suitable for use in far-forward deployed environments. The current diagnostic capabilities for battlefield wound infections are limited and time-consuming, resulting in delays in treatment and medical intervention decisions. The proposed technology should enable rapid diagnosis (less than 2 hours) at the point of injury, improving patient outcomes and reducing morbidity and mortality. The technology should be compatible with wet/dry environments, require minimum logistical support, and be stable in long-term storage. It should also be easy to use with little training and provide unambiguous primary output. The technology must include a plan for FDA clearance and should align with CLIA-waived complexity standards. The SBIR program consists of three phases: Phase I focuses on demonstrating scientific and technical feasibility, Phase II involves refining the technology and integrating it with a rapid diagnostic platform, and Phase III aims to secure FDA approval and transition the technology for commercial use in both civilian and military settings. The proposal submission deadline is March 31, 2025. More information can be found on the grants.gov website or the DOD SBIR/STTR Opportunities page.
DOD SBIR 24.4 Annual - Sample Collection and Processing Methods to Support Battlefield Wound Infection Diagnostics (Direct to Phase II)
Active
Department of Defense
The Department of Defense (DOD) is seeking proposals for a Small Business Innovation Research (SBIR) program focused on the topic of "Sample Collection and Processing Methods to Support Battlefield Wound Infection Diagnostics (Direct to Phase II)". The Defense Health Agency is the specific branch of the DOD overseeing this topic. The objective is to develop a simple-to-use sample collection and processing method that can accurately detect specific fungal and bacterial species commonly associated with complex battlefield wound infections. The technology should be capable of preparing an adequate specimen for identification and detection in far-forward deployed environments. The current diagnostic capabilities for battlefield wound infections are limited and time-consuming, leading to delays in treatment and medical intervention decisions. The proposed technology should provide rapid diagnostics with a sample collection-to-result time of less than 2 hours, improving patient outcomes and reducing morbidity and mortality. The technology should be compatible with wet/dry environments, require minimum logistical support, and be stable in long-term storage. It should also be easy to use with little training and provide unambiguous primary output. The technology must include a plan for FDA clearance and should align with CLIA-waived complexity standards. The SBIR program consists of three phases: Phase I focuses on demonstrating scientific and technical feasibility, Phase II involves refining the technology and integrating it with a rapid diagnostic platform, and Phase III aims to secure FDA approval and commercialize the technology for both civilian and military settings. The government may propose further harmonization of the technology with other relevant products to meet additional DoD requirements. The solicitation is open until March 31, 2025. More information can be found on the grants.gov website or the DOD SBIR/STTR Opportunities page.
NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44 Clinical Trial Required)
Active
Department of Health and Human Services
The Department of Health and Human Services, specifically the National Institutes of Health, is seeking proposals for the NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44 Clinical Trial Required). This solicitation encourages Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to implement investigator-initiated clinical trials, including mechanistic studies associated with clinical trials. The program supports milestone-driven, hypothesis-driven clinical trials related to the research mission of the NIAID that address high-priority research areas. The solicitation encourages high-risk clinical studies, which involve non-routine interventions, administration of an unlicensed product, or administration of a licensed product for an unapproved indication. Mechanistic studies are also encouraged. The funding supports the conduct, completion, and analysis of a single clinical trial, including activities such as training of study personnel, enrollment and recruitment of study subjects, data collection and management, laboratory work, safety monitoring, and regulatory activities. The project duration is not specified, but the application due dates are provided. More information can be found on the grants.gov website.
SBIR Phase IIB Bridge Awards to Accelerate the Development of Cancer-Relevant Technologies Toward Commercialization (R44 Clinical Trial Optional)
Active
Department of Health and Human Services
The Department of Health and Human Services, specifically the National Institutes of Health, is seeking proposals for SBIR Phase IIB Bridge Awards to accelerate the development of cancer-relevant technologies toward commercialization. This funding opportunity aims to support small business concerns (SBCs) that have previously received SBIR or STTR Phase II awards from any Federal agency. The goal is to assist applicants in pursuing the next milestone necessary to advance a promising product or service along a commercialization pathway. The focus is on cancer therapeutics, imaging technologies, diagnostics, prevention and control tools, and model systems for cancer research. The funding will prioritize projects that have secured substantial independent third-party investor funds and those that require approval from a Federal regulatory agency. The application due date is August 21, 2024, and more information can be found at the solicitation agency URL: [link](https://grants.nih.gov/grants/guide/rfa-files/RFA-CA-24-022.html).
Developing Regulated Therapeutic and Diagnostic Solutions for Patients Affected by Opioid and/or Stimulants use Disorders (OUD/StUD) (R43/R44 - Clinical Trial Optional)
Active
Department of Health and Human Services
The Department of Health and Human Services, specifically the National Institutes of Health, is seeking proposals for the development of regulated therapeutic and diagnostic solutions for patients affected by opioid and/or stimulants use disorders (OUD/StUD). The current drug crisis involving opioids and stimulants has resulted in a significant number of deaths and a need for comprehensive solutions. This funding opportunity aims to support research and development activities for novel medical products that address the needs of patients suffering from OUD/StUD. The two areas of focus are pharmacotherapeutics (small molecules, biologics, natural products, etc.) and medical therapeutic and diagnostic devices (imaging technologies, therapeutic devices, diagnostic assays, etc.). The projects proposed should aim to establish technical feasibility, commercial potential, and the quality of performance of the small business awardee organization. The funding opportunity includes Phase I, Phase II, Fast Track, and Direct to Phase II applications. The deadline for applications is February 15, 2025. For more information and to apply, visit the grants.gov website or the solicitation agency URL provided.