OPEN TOPIC - Expeditionary Biologics-on-Demand (BOND)
SBIR Opportunity Analysis
The Department of Defense’s CBD is seeking SBIR proposals for the open-topic Expeditionary Biologics-on-Demand (BOND) effort to develop portable, on-demand protein production for expeditionary and point-of-care use. The work centers on a modular BOND platform that can produce high-purity proteins with consistent quality, with Phase I focused on feasibility using an existing platform and Phase II aimed at a ruggedized system capable of reproducible, scalable GMP-like output. Key technical emphasis includes automated process control, soft sensors, machine learning, real-time analytics, and related improvements such as lysate optimization, sensor validation, and resin modification, with the goal of demonstrating consistent weekly batch quality. The solicitation opens April 15, 2026, and proposals are due May 13, 2026, at 4:00 PM.