GrantPostedDiscretionary

NHLBI TOPMed: Omics Phenotypes of Heart, Lung, and Blood Disorders (X01 - Clinical Trial Not Allowed)

National Institutes of Health
PAR-25-447
Application Deadline
May 8, 2028
753 days left
Days Remaining
753
Until deadline
Award Ceiling
Total Program Funding

Grant Opportunity Analysis

The National Institutes of Health (NIH) has announced a funding opportunity titled "NHLBI TOPMed: Omics Phenotypes of Heart, Lung, and Blood Disorders (X01 - Clinical Trial Not Allowed)." This initiative invites applications to leverage the NHLBI-funded TransOmics for Precision Medicine (TOPMed) program to generate integrated genetic and multi-omics data aimed at uncovering the molecular mechanisms underlying Heart, Lung, Blood, and Sleep (HLBS) disorders. The program is significant for advancing the understanding of genetic factors contributing to HLBS diseases, with a focus on transitioning from genetic associations to molecular insights, potentially utilizing artificial intelligence and machine learning tools. No direct funding will be provided; instead, successful applicants will gain access to omics assay resources and are expected to contribute data to public NIH-designated controlled-access databases. The application period opens on October 6, 2025, and closes on May 8, 2028, with a maximum project duration of three years. Interested parties can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries.

Eligible Applicants

Others
Additional Eligibility Information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grant Documents

2 Files
PAR-25-447-Full-Announcement.html
HTML0 KBSep 25, 2025
AI Summary
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PAR-25-447.html
HTML114 KBSep 25, 2025
AI Summary
The Department of Health and Human Services is reissuing a Notice of Funding Opportunity (NOFO) PAR-25-447 for the NHLBI TOPMed program, titled “Omics Phenotypes of Heart, Lung, and Blood Disorders.” This X01 Resource Access Award invites applications to utilize TOPMed's capacity to generate integrated genetic and multi-omics data to uncover the molecular mechanisms of Heart, Lung, Blood, and Sleep (HLBS) disorders. No direct funding will be provided; instead, successful applicants will gain access to omics assay resources and contribute data to public NIH-designated controlled-access databases like dbGaP and NHLBI’s BioData Catalyst. The goal is to advance understanding from genetic associations to molecular and cellular contributions to HLBS diseases, potentially leveraging AI and ML. Key dates include an open date of October 6, 2025, and an expiration date of May 9, 2028. Up to 10 projects are anticipated to be approved, with a maximum project period of three years. Eligible applicants include various organizations, including foreign entities, but applications involving foreign subawards/subcontracts are not allowed. Review criteria emphasize scientific merit, the potential to enrich existing TOPMed datasets, and robust data-sharing plans.

Related Grant Opportunities

Project Timeline

postedOriginal Opportunity PostedSep 22, 2025
deadlineApplication DeadlineMay 8, 2028
expiryArchive DateJun 13, 2028

Funding Details

No cost sharing required

Agency & Classification

Agency
National Institutes of Health(HHS-NIH11)
Funding Category
Health
Funding Instrument
Grant

Grantor Contact

CFDA Numbers

93.840

Official Sources