GrantPostedDiscretionary

Assay Development and Screening for Discovery of Validated Chemical Hits for Brain Disorders (R01 Clinical Trial Not Allowed)

National Institutes of Health
PAR-25-063
Application Deadline
May 7, 2026
33 days left
Days Remaining
33
Until deadline
Award Ceiling
Total Program Funding

Grant Opportunity Analysis

The National Institutes of Health (NIH) is offering a funding opportunity for Research Project Grants (R01) aimed at the development of screening assays for drug candidates targeting psychiatric disorders. The primary objectives of this initiative are to stimulate research in the discovery and development of novel small molecules that can potentially treat mental illnesses, as well as to validate compounds that demonstrate desired biological activity through rigorous screening processes. This funding is crucial for advancing therapeutic options for conditions such as depression, schizophrenia, and PTSD, and it encourages applicants to align their proposals with the National Institute of Mental Health (NIMH) priorities. Interested applicants must submit their proposals by May 7, 2026, and can find additional information and application guidelines at the NIH grants website or contact NIH Grants Information at grantsinfo@nih.gov for further inquiries.

Eligible Applicants

Others
Additional Eligibility Information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grant Documents

2 Files
PAR-25-063-Full-Announcement.html
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PAR-25-063.html
HTML126 KBNov 7, 2024
AI Summary
The National Institutes of Health (NIH), through the National Institute of Mental Health (NIMH), is offering funding for Research Project Grants (R01) aimed at developing screening assays for drug candidates treating mental illnesses. The initiative focuses on validating "hits," compounds that exhibit desired biological activity in initial screenings and confirmed in follow-up assays. The funding opportunity includes three research stages: assay development, primary screening implementation, and hit validation. Applications must address the project's significance and innovation and delineate plans for research rigor, feasibility, and organizational capacity. Eligible entities include higher education institutions, nonprofits, for-profit organizations, and governmental bodies, with a maximum project period of five years. The funding's purpose is to stimulate research into novel therapeutics for psychiatric conditions such as depression, schizophrenia, and PTSD. Applicants are encouraged to align their proposals with NIMH priorities and include appropriate data management and sharing plans post-approval. The application submission process involves adherence to the NIH application guide, with strict compliance to improve the likelihood of funding success.

Related Grant Opportunities

Project Timeline

postedOriginal Opportunity PostedNov 6, 2024
deadlineApplication DeadlineMay 7, 2026
expiryArchive DateJun 12, 2026

Funding Details

No cost sharing required

Agency & Classification

Agency
National Institutes of Health(HHS-NIH11)
Funding Category
Health
Funding Instrument
Grant

Grantor Contact

CFDA Numbers

93.242

Official Sources