Addressing Methodological Challenges with Clinical Trials of Rapid-Acting Psychotropic Interventional Drugs (RAPIDs) (R01 Clinical Trial Required)
Grant Opportunity Analysis
The Department of Health and Human Services, through the National Institutes of Health, is issuing a grant opportunity to address methodological challenges in clinical trials of rapid-acting psychotropic interventional drugs (RAPIDs). The work is intended to clarify the therapeutic effects of RAPIDs and improve how they are delivered, monitored, and sustained, while also strengthening the rigor and interpretability of the clinical trial data. Key areas include maximizing blind integrity, minimizing expectancy bias, evaluating control comparisons, and identifying objective biological measures, and applications must propose clinical trials. The NOFO provides up to $5,500,000 in FY 2027 for up to six awards with a project period of up to five years, and applications are due by October 10, 2026; the listed contact is DTRcommunications@nih.gov.
Eligible Applicants
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.