Causal Hypotheses on the Oral-Systemic Health Impacts of Human Behaviors among People with Chronic Conditions (U01 Clinical Trial Not Allowed)
Grant Opportunity Analysis
The National Institutes of Health, through the National Institute of Dental and Craniofacial Research and the Tribal Health Research Office, is offering a cooperative agreement to support innovative research on causal hypotheses about how human behaviors affect oral-systemic health among people with chronic conditions. The work is intended to develop, refine, and test hypotheses about biological, biopsychosocial, environmental, psychological, and related factors that trigger behaviors and influence oral-systemic health outcomes, including downstream effects. The opportunity is for a U01 mechanism and does not allow clinical trials, with an emphasis on understanding health impacts in conditions such as inflammation, craniofacial disorders, diabetes, and cardiovascular disease. It was posted June 4, 2026, has application due dates through October 5, 2028, expires July 6, 2029, and lists an award ceiling of $500,000 with no cost sharing required.
Eligible Applicants
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.