The National Institutes of Health (NIH) is offering the Seed Instrumentation Support (SIS) Program, a federal grant opportunity aimed at enhancing research capacity through the purchase of a single commercially available biomedical research instrument. Eligible applicants, specifically private institutions of higher education, are encouraged to apply for funding that ranges from a minimum of $50,000 to a maximum of $400,000, with a total program funding of $5 million and an expected 15 awards to be granted. This initiative is crucial for fostering collaborative research, enabling reproducible data generation, and strengthening long-term research capabilities within the biomedical field. Interested parties can reach out to Xiang-Ning Li, MD, PhD, at xiang-ning.li@nih.gov or by phone at 301-435-1744 for further information, with applications due by July 1, 2026, and awards anticipated to be made by May 1, 2027.