The Genesis Mission: Transforming Science and Energy with AI
Grant Opportunity Analysis
The DOE Office of Science and partner DOE offices are seeking applications for the Genesis Mission to accelerate scientific discovery and R&D workflows using novel AI models and frameworks that support energy, environmental, and nuclear mission needs. The work centers on interdisciplinary teams developing AI models and workflows across topic areas such as advanced manufacturing, biotechnology, critical materials, nuclear fission and fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy. Applications are structured for FY26 Phase I small teams and Phase II large teams, with a strong emphasis on proposed computing needs, team expertise, data storage, and any use or generation of proprietary, restricted, or export-controlled information. Successful efforts may be integrated into the American Science Cloud and teams are encouraged to draw on DOE/NNSA resources, national laboratories, industry, and academia. Applications are due December 17, 2026, and the opportunity lists an award range of $500,000 to $5,000,000, with questions directed to GenesisMissionNOFO@science.doe.gov.