The National Institutes of Health (NIH) is offering a grant opportunity titled "BRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61 Basic Experimental Studies with Humans Required)." This initiative aims to solicit exploratory research projects that leverage invasive surgical procedures to record and stimulate neuronal activity in the human brain, focusing on understanding the dynamics of neuronal networks and their relation to human sensations, perceptions, and behaviors. The research is intended to lay the groundwork for future projects that utilize these invasive technologies, with successful applicants joining a consortium to establish standards of practice and share data within the scientific community. Interested small businesses can contact Dr. Merav Sabri at BRAINeROH@ninds.nih.gov or call 301-827-0908 for more information, with applications expected to be submitted by September 15, 2025, and project start dates anticipated for July 29, 2026.