Cooperative AgreementPostedDiscretionary

Limited Competition: Outcomes of Electronic Medical Records and Genomics (eMERGE) Genomic Risk Assessment and Management Network - Clinical Sites (U01, Clinical Trial Required)

National Institutes of Health
RFA-HG-25-012
Application Deadline
Jan 13, 2026
Closed
Days Remaining
0
Deadline passed
Award Ceiling
$330,000
Total Program Funding
$5,800,000

Grant Opportunity Analysis

The National Institutes of Health (NIH) is offering a Limited Competition Notice of Funding Opportunity (NOFO) for the Outcomes of Electronic Medical Records and Genomics (eMERGE) Genomic Risk Assessment and Management Network – Clinical Sites. This initiative invites organizations previously funded under RFA-HG-19-013 and RFA-HG-19-014 to participate in a clinical trial aimed at assessing the long-term adherence to and outcomes of genomically informed risk assessments (GIRA) for approximately 25,000 patients. The program is crucial for understanding the effectiveness of GIRA-based preventative recommendations and identifying factors influencing patient adherence. Interested applicants must submit their proposals by January 30, 2026, with an estimated total program funding of $5.8 million allocated for ten awards over the fiscal years 2026 to 2029. For further inquiries, applicants can contact the Division of Genomic Medicine at NHGRI_DGMed@nih.gov.

Eligible Applicants

Others
Additional Eligibility Information

This is a limited competition NOFO. Only organizations funded under RFA-HG-19-013 and RFA-HG-19-014 are eligible to apply.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. This new requirement was effective, May 1, 2025.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Grant Documents

1 Files
RFA-HG-25-012-Full-Announcement.html
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AI Summary
The Department of Health and Human Services (NIH) is issuing a Limited Competition Notice of Funding Opportunity (NOFO) (RFA-HG-25-012) for the Outcomes of Electronic Medical Records and Genomics (eMERGE) Genomic Risk Assessment and Management Network – Clinical Sites. This reissued opportunity invites organizations previously funded under RFA-HG-19-013 and RFA-HG-19-014 to extend follow-up and collect outcome data from approximately 25,000 patients who received genomically informed risk assessments (GIRA). The project, a clinical trial, aims to assess the longer-term adherence to and outcomes of GIRA-based preventative recommendations, and identify factors influencing adherence. With an annual commitment of $5.8 million from FY 2026 to FY 2029 for ten awards, the NOFO requires applications by January 30, 2026, and emphasizes strict adherence to application guidelines, data sharing policies (including use of AnVIL and ClinVar), and collaborative participation within the eMERGE Network.

Related Grant Opportunities

Project Timeline

postedOriginal Opportunity PostedDec 23, 2025
deadlineApplication DeadlineJan 13, 2026
expiryArchive DateMar 14, 2026

Funding Details

Award Ceiling
$330,000
Est. Total Program Funding
$5,800,000
Expected Awards
10
No cost sharing required

Agency & Classification

Agency
National Institutes of Health(HHS-NIH11)
Funding Category
Health
Funding Instrument
Cooperative Agreement

Grantor Contact

CFDA Numbers

93.172

Official Sources