The National Institutes of Health (NIH) is offering a Limited Competition Notice of Funding Opportunity (NOFO) for the Outcomes of Electronic Medical Records and Genomics (eMERGE) Genomic Risk Assessment and Management Network – Clinical Sites. This initiative invites organizations previously funded under RFA-HG-19-013 and RFA-HG-19-014 to participate in a clinical trial aimed at assessing the long-term adherence to and outcomes of genomically informed risk assessments (GIRA) for approximately 25,000 patients. The program is crucial for understanding the effectiveness of GIRA-based preventative recommendations and identifying factors influencing patient adherence. Interested applicants must submit their proposals by January 30, 2026, with an estimated total program funding of $5.8 million allocated for ten awards over the fiscal years 2026 to 2029. For further inquiries, applicants can contact the Division of Genomic Medicine at NHGRI_DGMed@nih.gov.

RFA-HG-25-012-Full-Announcement.html

The Department of Health and Human Services (NIH) is issuing a Limited Competition Notice of Funding Opportunity (NOFO) (RFA-HG-25-012) for the Outcomes of Electronic Medical Records and Genomics (eMERGE) Genomic Risk Assessment and Management Network – Clinical Sites. This reissued opportunity invites organizations previously funded under RFA-HG-19-013 and RFA-HG-19-014 to extend follow-up and collect outcome data from approximately 25,000 patients who received genomically informed risk assessments (GIRA). The project, a clinical trial, aims to assess the longer-term adherence to and outcomes of GIRA-based preventative recommendations, and identify factors influencing adherence. With an annual commitment of $5.8 million from FY 2026 to FY 2029 for ten awards, the NOFO requires applications by January 30, 2026, and emphasizes strict adherence to application guidelines, data sharing policies (including use of AnVIL and ClinVar), and collaborative participation within the eMERGE Network.

This Limited Competition Notice of Funding Opportunity (NOFO) invites recipient organizations funded under the Electronic Medical Records and Genomics (eMERGE): Genomic Risk Assessment and Management Network Clinical Sites (RFA-HG-19-013 and RFA-HG-19-014) to participate in the Outcomes of Electronic Medical Records and Genomics (eMERGE) Genomic Risk Assessment and Management Network. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, the applications will be peer-reviewed, and only meritorious applications will be considered. The eMERGE Network will extend through April 2030 follow-up and collection of outcome data on the roughly 25,000 patients receiving genomically informed risk assessment (GIRA) and management recommendations.This is a Notice of Funding Opportunity (NOFO) for a Limited Competition that will invite application(s) from eligible organization(s) to apply. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding.

Division of Genomic Medicine&lt;br/&gt;NHGRI_DGMed@nih.gov

Limited Competition: Outcomes of Electronic Medical Records and Genomics (eMERGE) Genomic Risk Assessment and Management Network - Clinical Sites (U01, Clinical Trial Required)

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