The Advanced Research Projects Agency-Energy (ARPA-E) of the U.S. Department of Energy has issued a Request for Information (RFI) aimed at securing new sources of helium for advanced energy applications. This initiative seeks input on transformative technologies along the helium supply chain, specifically alternatives to helium sourced from natural gas, with a focus on innovative methods for locating new helium sources and enhancing recovery and recycling technologies. Helium is critical for various energy-related technologies, including semiconductor manufacturing and quantum computing, and the U.S. faces a projected global helium shortfall by 2040, making a sustainable domestic supply essential. Interested parties are encouraged to submit their responses in PDF format to ARPA-E-RFI@hq.doe.gov by 5:00 p.m. Eastern Time on March 15, 2024, as this RFI does not constitute a funding opportunity announcement and is solely for gathering information. For further details, visit the ARPA-E eXCHANGE at https://arpa-e-foa.energy.gov.