The Advanced Research Projects Agency Energy (ARPA-E) is seeking input for a potential program focused on securing new sources of helium for advanced energy applications. The purpose of this Request for Information (RFI) is to gather ideas for innovative technologies that can decrease the cost of helium production and ensure its availability for next-generation energy technologies. Specifically, ARPA-E is interested in concepts that can develop mapping technologies to locate new helium sources and produce helium using advanced separation technologies. Helium is crucial for various energy-related technologies such as semiconductor manufacturing, fiber optics, quantum computing, and reactor cooling. The United States currently uses approximately 45 million cubic meters of helium annually, with 50% dedicated to industrial and scientific purposes related to energy. However, the U.S. has seen a decline in its global helium production share, and a helium shortfall of 70 million-110 million cubic meters is anticipated by 2040. To maintain technological leadership in energy innovation, it is essential to secure a robust domestic supply of helium. The RFI is not seeking applications for financial assistance at this time, but aims to gather information to inform the possible formulation of future programs. For more details, please visit the ARPA-E eXCHANGE website. Responses to this RFI should be submitted in PDF format to ARPA-E-RFI@hq.doe.gov by 5:00 p.m. Eastern Time on March 15, 2024.