Nationwide Cohort to Estimate Burden of Respiratory Viruses and Immunologic Response (Blood Donor Cohort)

Active
No
Status
Posted
Published Date
December 12th, 2023
Close Date
February 16th, 2024
Total Funding
$26,500,000.00
Award Ceiling
$4,500,000.00
Award Floor
$3,000,000.00
Expected No. Awards
1
Opportunity No.
RFA-IP-24-046

Agency

Centers for Disease Control and Prevention - ERA (HHS-CDC-HHSCDCERA)

Eligible Applicants

For-Profit Organizations

Funding Category

Health

Funding Instrument

Cooperative Agreement

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Summary

The Centers for Disease Control and Prevention - ERA is offering a nationwide cooperative agreement grant opportunity titled "Nationwide Cohort to Estimate Burden of Respiratory Viruses and Immunologic Response (Blood Donor Cohort)". This project aims to establish and sustain a national longitudinal cohort of repeat blood donors to monitor changes in antibody titers against common or novel respiratory viruses. The cohort will also survey donors to assess risk factors for infection, vaccination status, respiratory symptoms, and severe illness. Additionally, a repository will be established for further analysis as new assays to measure the immune response to respiratory virus infections are developed. The grant has an estimated total program funding of $26,500,000 and expects to make one award. The close date for electronically submitted applications is February 16, 2024, at 11:59 pm ET. For more information, contact Dr. Jamal Bankhead at JBankhead@cdc.gov.

Description

This project would establish and sustain a national longitudinal cohort of repeat blood donors with the purpose of monitoring changes in antibody titers against common or novel respiratory viruses; surveying the donors to assess for risk factors for infection, vaccination status, respiratory symptoms, and severe illness; and establishing a repository for further analysis as new assays to measure the immune response to respiratory virus infections are developed.During the COVID-19 pandemic, CDC used a contract mechanism to fund national serosurveillance studies, which used regular antibody assessments and surveys to monitor the burden of infection, risk factors for infection, and explore the duration and extend of immunity by population throughout the US (2020-2022). By 2022, algorithms for using quantitative antibody titers to detect reinfection were established and tested, creating novel systems for monitoring burden even in the setting of high overall seroprevalence.Adapting these tools to the current context, this research cooperative agreement would establish a large-scale longitudinal cohort (>50,000 persons) of repeat blood donors with the purpose of: 1) estimating the national burden of incident SARS-CoV-2 infection, and further adapting the approach to other respiratory viruses as technology allows including Respiratory Syncytial Virus, Influenza, Human Metapneumovirus, EVD-68, and others; 2) determining antibody thresholds for protection across multiple respiratory viruses; 3) assessing state- or region-specific population-level immunity to/risk for infection through tracking median antibody titers within various populations; and 4) monitoring waning immunity and changes in immune capabilities in the context of ongoing viral evolution.

Contact Information

Opportunity Lifecycle

Title
Type
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