Precision Approaches in Radiation Synthetic Combinations (PAIRS, RP1 Clinical Trial Optional)
Grant Opportunity Analysis
The National Institutes of Health (NIH) is offering a grant opportunity titled "Precision Approaches in Radiation Synthetic Combinations (PAIRS, RP1 Clinical Trial Optional)" aimed at advancing cancer treatment strategies. This funding initiative seeks research projects that explore actionable synthetic vulnerabilities in conjunction with tumor responses to radiation therapy, with the goal of developing innovative radiation-synthetic combination strategies for precision medicine. The PAIRS program emphasizes the importance of context-dependent vulnerabilities and aims to enhance therapeutic outcomes while minimizing harm to normal tissues. Interested applicants can submit proposals for either exploratory/developmental projects (up to 2 years) or research projects (4 to 5 years), with no cost-sharing requirement. For further inquiries, applicants may contact the NCI PAIRS Program at pairsresearchgrants@nih.gov or call 240-276-5703. The estimated synopsis close date is November 11, 2026, with awards expected to be made by July 1, 2027.
Eligible Applicants
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).