GrantPostedDiscretionary

Optimizing Treatment Strategies for Adult Attention-Deficit Hyperactivity Disorder (ADHD) (R01 Clinical Trial Required)

National Institutes of Health
RFA-MH-26-195
Application Deadline
Nov 25, 2025
Closed
Days Remaining
0
Deadline passed
Award Ceiling
Total Program Funding

Grant Opportunity Analysis

The National Institutes of Health (NIH) has announced a funding opportunity titled "Optimizing Treatment Strategies for Adult Attention-Deficit Hyperactivity Disorder (ADHD) (R01 Clinical Trial Required)" aimed at advancing clinical research on non-stimulant treatment options for adults diagnosed with ADHD. This initiative seeks applications for clinical trials that explore non-stimulant medications, psychosocial interventions, and device-based treatments, particularly in cases where stimulant therapies are ineffective, intolerable, or undesirable. The research is expected to take place in community practice settings to enhance scalability and utility, with a focus on participants aged 18 and older who meet DSM-5-TR criteria for ADHD, including those with comorbid conditions. A total funding amount of $3,000,000 is available for up to four awards, with a maximum project duration of five years. Interested applicants must comply with NIH data management policies and submit their proposals by November 25, 2025; for further inquiries, they can contact NIH Grants Information at grantsinfo@nih.gov.

Eligible Applicants

Others
Additional Eligibility Information

Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Grant Documents

2 Files
RFA-MH-26-195-Full-Announcement.html
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RFA-MH-26-195.html
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AI Summary
The Department of Health and Human Services (HHS), specifically the National Institute of Mental Health (NIMH), has issued a funding opportunity (RFA-MH-26-195) for clinical research to optimize non-stimulant treatment strategies for adult Attention-Deficit Hyperactivity Disorder (ADHD). This initiative seeks applications for clinical trials focusing on non-stimulant medications, psychosocial interventions, and device-based treatments, used sequentially or in combination, for adults where stimulant monotherapy is insufficient, intolerable, or undesirable. The research must include an assessment of target engagement to understand the intervention's mechanisms of action and should take place in community practice settings to ensure scalability and utility for end-users. Applications must include participants aged 18 and older, meet DSM-5-TR criteria for ADHD, and consider comorbid conditions. Funding of $3,000,000 is available for up to four awards, with a maximum project period of five years. All applicants must comply with NIH and NIMH data management and sharing policies, including submitting data to the National Institute of Mental Health Data Archive (NDA).

Related Grant Opportunities

Project Timeline

postedOriginal Opportunity PostedSep 17, 2025
deadlineApplication DeadlineNov 25, 2025
expiryArchive DateDec 31, 2025

Funding Details

No cost sharing required

Agency & Classification

Agency
National Institutes of Health(HHS-NIH11)
Funding Category
Health
Funding Instrument
Grant

Grantor Contact

CFDA Numbers

93.242

Official Sources