NIDCR Prospective Observational or Biomarker Validation Study Cooperative Agreement (U01 Clinical Trial Not Allowed)
Grant Opportunity Analysis
The National Institute of Dental and Craniofacial Research, an agency of the National Institutes of Health, is offering cooperative agreements under funding opportunity PAR-27-058 to support investigator-initiated observational or biomarker validation studies. Funded projects must focus on advancing dental, oral, and craniofacial health by performing prospective collections and analyses of data and biospecimens, though biomarker discovery and clinical trials are explicitly excluded. The program emphasizes rigorous study designs, strong collaborative efforts, and strict adherence to appropriate methodologies for biospecimen handling. Domestic organizations are eligible to apply for awards providing up to $500,000 in annual direct costs for a period of performance of up to five years. Applications are accepted starting September 5, 2026, and must be submitted prior to the funding opportunity's close date on July 5, 2029.
Eligible Applicants
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.