The National Institutes of Health (NIH) is offering a funding opportunity for Resource-Related Research Projects aimed at developing models and methodologies for studying human health and diseases, specifically through the R24 grant mechanism, which does not allow clinical trials. This initiative, led by the Office of Research Infrastructure Programs (ORIP), seeks applications that focus on creating broadly applicable research models or new approach methodologies (NAMs) that address diseases impacting multiple organ systems, with a requirement that projects demonstrate relevance to two or more NIH Institutes or Centers. The NIH plans to allocate $5 million annually from fiscal years 2026 to 2029, funding at least six awards each year, with a maximum project duration of four years. Interested applicants, excluding foreign organizations, must complete federal registrations prior to submission and can direct inquiries to ORIPDCM@mail.nih.gov.