The National Institutes of Health (NIH) is offering a funding opportunity for Resource-Related Research Projects aimed at developing models and methodologies for studying human health and diseases, specifically through the R24 grant mechanism, which does not allow clinical trials. This initiative, led by the Office of Research Infrastructure Programs (ORIP), seeks applications that focus on creating broadly applicable research models or new approach methodologies (NAMs) that can impact multiple organ systems and align with the interests of two or more NIH Institutes or Centers. The NIH plans to allocate $5 million annually from FY 2026 to FY 2029, with at least six awards expected each year, and projects can last up to four years. Interested applicants, excluding foreign organizations, must complete federal registrations prior to submission and can reach out to ORIPDCM@mail.nih.gov for further information.