The National Institutes of Health (NIH) is offering a funding opportunity for Resource-Related Research Projects aimed at developing models and methodologies for studying human health and diseases, specifically through the R24 grant mechanism, which does not allow clinical trials. This initiative, led by the Office of Research Infrastructure Programs (ORIP), seeks applications that focus on creating broadly applicable research models or new approach methodologies (NAMs) that can impact multiple organ systems and align with the interests of two or more NIH Institutes or Centers. The NIH plans to allocate $5 million annually from FY 2026 to FY 2029, with at least six awards expected each year, and projects can last up to four years. Interested applicants, excluding foreign organizations, must complete federal registrations prior to submission and can reach out to ORIPDCM@mail.nih.gov for further information.

RFA-OD-25-010-Full-Announcement.html

The Department of Health and Human Services (NIH) is reissuing a funding opportunity (RFA-OD-25-010) for Resource-Related Research Projects (R24, Clinical Trials Not Allowed). This initiative, led by the Office of Research Infrastructure Programs (ORIP), encourages grant applications for developing, characterizing, or improving research models of human health and diseases, new approach methodologies (NAMs), or enhancing access to information about disease models. Projects must have broad applicability to two or more NIH Institutes or Centers (ICs) and evaluate diseases impacting multiple organ systems. Applications focusing on specific diseases or limited research areas will not be accepted. The NIH plans to commit $5,000,000 annually from FY 2026-2029, funding at least six awards per fiscal year, with a maximum project duration of four years. Eligible applicants include various organizations, but foreign organizations are excluded. All applicants must complete federal registrations, including SAM.gov and eRA Commons, prior to submission.

The Office of Research Infrastructure Programs (ORIP) encourages grant applications aimed at developing, characterizing, or improving research models of human health and diseases; developing biology based new approach methodologies (NAMs) applicable to human health and diseases; or improving access to information about or generated from the use of models of human disease. The models, including NAMs, and related biological materials developed must be broadly applicable to the scientific interests of two or more NIH Institutes or Centers (ICs) and must evaluate diseases and processes that impact multiple organ systems in order to align with the ORIP&quot;s NIH-wide mission and programs. Applications must describe the need for and the potential impact of the proposed resources on the research community across a range of scientific disciplines supported by multiple NIH ICs. Applications to develop models that relate strictly to a specific disease or a select area of research or that do not have a broad impact on the NIH-wide research community will not be accepted. Projects that predominantly address the research interests of one NIH IC but are only peripherally related to the research interests of other ICs will also not be accepted, if submitted in response to this notice of funding opportunity (NOFO).

Office of Research Infrastructure Programs (ORIP)&lt;br/&gt;ORIPDCM@mail.nih.gov

Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed)

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