GrantPostedDiscretionary

Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed)

National Institutes of Health
RFA-OD-25-010
Application Deadline
Sep 28, 2028
908 days left
Days Remaining
908
Until deadline
Award Ceiling
Total Program Funding
$5,000,000

Grant Opportunity Analysis

The National Institutes of Health (NIH) is offering a funding opportunity for Resource-Related Research Projects aimed at developing models and methodologies for studying human health and diseases, specifically through the R24 grant mechanism, which does not allow clinical trials. This initiative, led by the Office of Research Infrastructure Programs (ORIP), seeks applications that focus on creating broadly applicable research models or new approach methodologies (NAMs) that can impact multiple organ systems and align with the interests of two or more NIH Institutes or Centers. The NIH plans to allocate $5 million annually from FY 2026 to FY 2029, with at least six awards expected each year, and projects can last up to four years. Interested applicants, excluding foreign organizations, must complete federal registrations prior to submission and can reach out to ORIPDCM@mail.nih.gov for further information.

Eligible Applicants

Others
Additional Eligibility Information

Refer to Section III. Eligibility Information of the NOFO for additional information on eligibility.Foreign Organizations/Foreign CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Grant Documents

1 Files
RFA-OD-25-010-Full-Announcement.html
HTML113 KBDec 10, 2025
AI Summary
The Department of Health and Human Services (NIH) is reissuing a funding opportunity (RFA-OD-25-010) for Resource-Related Research Projects (R24, Clinical Trials Not Allowed). This initiative, led by the Office of Research Infrastructure Programs (ORIP), encourages grant applications for developing, characterizing, or improving research models of human health and diseases, new approach methodologies (NAMs), or enhancing access to information about disease models. Projects must have broad applicability to two or more NIH Institutes or Centers (ICs) and evaluate diseases impacting multiple organ systems. Applications focusing on specific diseases or limited research areas will not be accepted. The NIH plans to commit $5,000,000 annually from FY 2026-2029, funding at least six awards per fiscal year, with a maximum project duration of four years. Eligible applicants include various organizations, but foreign organizations are excluded. All applicants must complete federal registrations, including SAM.gov and eRA Commons, prior to submission.

Related Grant Opportunities

Project Timeline

postedOriginal Opportunity PostedDec 5, 2025
deadlineApplication DeadlineSep 28, 2028
expiryArchive DateNov 2, 2028

Funding Details

Est. Total Program Funding
$5,000,000
Expected Awards
6
No cost sharing required

Agency & Classification

Agency
National Institutes of Health(HHS-NIH11)
Funding Category
Health
Funding Instrument
Grant

Grantor Contact

CFDA Numbers

93.351

Official Sources