The National Institutes of Health (NIH) is offering the Shared Instrumentation Grant (SIG) Program, aimed at supporting groups of NIH-supported investigators in acquiring or upgrading state-of-the-art instrumentation for shared use in research. This program consolidates three existing instrumentation programs and requires that the instruments purchased be optimally shared among users to enhance research efficiency, reproducibility, and collaboration across broad research communities. The funding amounts range from a minimum of $300,000 to a maximum of $5,000,000, with an estimated total program funding of $83,000,000 and approximately 102 awards expected. Interested applicants must meet cost-sharing requirements and can contact Xiang-Ning Li, MD, PhD, at xiang-ning.li@nih.gov or by phone at 301-435-1744 for further information. Key deadlines include an estimated synopsis close date of July 1, 2026, and an estimated award date of March 1, 2027.