The Department of Health and Human Services, through the NIH, announces the Support for Research Excellence (SuRE) Award program, aimed at enhancing biomedical research capacity at resource-limited higher education institutions. This funding opportunity (FON: PAR-25-414) targets institutions that struggle to access NIH Research Project Grants, specifically supporting investigator-initiated research across various biomedical fields. The SuRE awards enable eligible faculty to conduct research while engaging students in high-quality scientific experiences, ultimately enriching the research culture within these institutions. Eligible applicants are higher education institutions that award biomedical degrees and have received limited NIH funding (not exceeding $6 million annually in the past two years). The program allows applications of up to $100,000 in direct costs annually for a maximum of four years, with special emphasis on supporting institutions with significant Pell Grant student populations. Applications must undergo a rigorous review process, evaluating significance, innovation, rigor, feasibility, and investigator expertise. Reviewers will assess the potential for impactful scientific contributions and the involvement of students in research. The expected outcomes include an increase in successful research projects and student preparedness for careers in biomedical sciences, thereby strengthening the broader research community within the U.S. and promoting diversity in scientific inquiry.