The National Institutes of Health (NIH) is offering a funding opportunity titled "Dissemination and Implementation Research in Health (R21 Clinical Trial Optional)" aimed at supporting studies that identify, develop, and test strategies to overcome barriers to the adoption and sustainability of evidence-based health interventions. The initiative encourages applications that promote equitable dissemination among underrepresented communities and address the de-implementation of ineffective practices, with a focus on innovative strategies for embedding these approaches into clinical and community settings. Interested applicants, including various educational institutions and community organizations, can submit proposals through the R21 Exploratory/Developmental Research Grant mechanism, with applications due by January 7, 2028. For further inquiries, applicants can contact NIH Grants Information at grantsinfo@nih.gov or visit the additional information link at https://grants.nih.gov/grants/guide/pa-files/PAR-25-143.html.