The National Science Foundation (NSF) has posted a grant opportunity titled "Division of Molecular and Cellular Biosciences Core Programs". This grant aims to support research that uncovers the fundamental properties of living systems at the atomic, molecular, subcellular, and cellular scales. The program prioritizes projects that advance our understanding of the structure, function, and evolution of molecular, subcellular, and cellular systems, with a focus on quantitative and predictive knowledge of complex behavior and emergent properties. The grant encourages research that incorporates insights and approaches from other scientific disciplines, such as chemistry, computer science, engineering, mathematics, and physics, to illuminate the principles that govern life at the molecular and cellular level. The grant also supports research that utilizes a diverse range of model and non-model animals, plants, and microbes across the tree of life. Proposals that pursue potentially transformative ideas are welcome, even if they entail higher risk. The grant seeks proposals in research areas supported by the four MCB core clusters, including the structure, dynamics, and function of biomolecules and supramolecular assemblies; the organization, processing, expression, regulation, and evolution of genetic and epigenetic information; cellular structure, properties, and function across broad spatiotemporal scales; and systems and/or synthetic biology to study complex interactions through modeling or manipulation or design of living systems at the molecular-to-cellular scale. The grant encourages projects that integrate across scales, investigate molecular and cellular evolution, synergize experimental research with computational or mathematical modeling, and develop innovative, broadly applicable methods and technologies. Projects that bridge the intellectual edges between MCB clusters are also welcome. The grant supports the participation of diverse talent in STEM, including historically under-represented or underserved populations, diverse institutions, and researchers from EPSCoR jurisdictions. It also encourages proposals that address priority areas associated with building a resilient planet and biotechnology and the bioeconomy. The grant emphasizes the importance of leveraging NSF resources to facilitate integration across the biological sciences, such as the National Ecological Observatory Network (NEON), data networks, synthesis centers, and institutes. While the grant supports basic research in all areas of the biological sciences, research focused exclusively on understanding human diseases and their treatment is normally outside the scope of funding. Proposals can be submitted anytime. For more information, please visit the NSF Publication 24-539 at http://www.nsf.gov/publications/pub_summ.jsp?ods_key=nsf24539.