Cellular Senescence Network (SenNet): SenNet Data Coordination and Integration Center (SenNet DCIC) (UM1 Clinical Trials Not Allowed)

This Notice of Funding Opportunity (RFA-RM-27-025) issued by the National Institutes of Health (NIH) solicits applications for the Cellular Senescence Network (SenNet) Data Coordination and Integration Center (SenNet DCIC). Administered by the National Institute on Aging (NIA) on behalf of the NIH Common Fund, this cooperative agreement mechanism (UM1 Activity Code) funds a single hub to serve as the central data and administrative core for Stage 2 of SenNet. The DCIC will manage, harmonize, integrate, and broadly disseminate consortium-generated single-cell and spatial multi-omic data to create public tissue-specific Senescence Atlases. Key technical priorities include establishing data submission, quality control, and provenance standards (FAIR principles); integrating Stage 1 healthy tissue data with Stage 2 diseased tissue data; maintaining a public 2D/3D visualization portal; and managing the SenNet Organization and Outreach Component (SOOC) to handle network logistics, educational programs, and cross-consortium collaboration. Applications open October 23, 2026, and are due November 23, 2026. Higher education, nonprofit, for-profit, government, and tribal entities are eligible, though foreign entities and foreign subawards are strictly prohibited. Total project periods can span up to 5 years, with annual direct budgets limited to approximately $3 million (including a mandatory $600,000 for SOOC functions). Awards involve substantial NIH programmatic participation. Recipients must maintain robust cybersecurity controls, uphold public data sharing, and manage controlled-access sensitive human data in designated NIH repositories.