The National Institutes of Health (NIH) is offering the Director's New Innovator Award Program (DP2 Clinical Trial Optional), aimed at supporting early-stage investigators with innovative research projects that have the potential for significant impact in the biomedical sciences. This grant program encourages applications from a diverse range of eligible applicants, including Indian/Native American Tribal Governments, faith-based organizations, and foreign institutions, with no cost-sharing or matching requirements. The total estimated funding for this program is $23 million, with an award ceiling and floor set at $475,000, and approximately 30 awards expected to be made. Interested applicants can reach out to the NIH Director's New Innovator Award Program via email at NewInnovatorAwards@mail.nih.gov, with applications due by August 19, 2026, and project start dates anticipated for September 30, 2026.