The National Institutes of Health (NIH) is offering the Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed), aimed at supporting innovative research projects that signify a new direction for early stage investigators (ESIs). Applicants must propose projects without any preliminary data and align their research with the mission of participating NIH Institutes and Centers, while clinical trials are explicitly prohibited. This grant initiative is crucial for fostering innovation among ESIs, allowing them to explore novel research avenues over a maximum project period of five years. Interested applicants should note that the first application deadline is August 25, 2025, and can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries.