GrantPostedDiscretionary

Advancing Global Health

Bureau of Global Health Security and Diplomacy
DFOP0017890
Application Deadline
Feb 14, 2027
270 days left
Days Remaining
270
Until deadline
Award Ceiling
$250,000,000
Total Program Funding
$2,147,483,647

Grant Opportunity Analysis

The U.S. Department of State’s Bureau of Global Health Security and Diplomacy is seeking grant applications under the Advancing Global Health annual program statement to support the America First Global Health Strategy, with a strong focus in the files on rapid outbreak response. The work centers on helping countries detect and contain infectious disease outbreaks at their source through projects that can support rapid activation, surge response, early detection, coordinated response, surveillance, immunization, medical countermeasures, and reinforcement of country health systems. The opportunity emphasizes speed, operational readiness, flexibility, country ownership, evidence-informed decision-making, coordination, sustainability, and feasibility in high-risk environments, with projects limited to five years or less. Statements of Interest are due by May 31, and the opportunity anticipates up to 10 awards totaling an estimated $290 million; questions or follow-up may be directed to GHSD-APS@state.gov.

Eligible Applicants

Unrestricted
Additional Eligibility Information

Please see APS instructions for eligibility criteria.

Grant Documents

9 Files
DFOP0017890 GHSD Advancing Global Health APS.pdf
PDF392 KBMar 8, 2026
AI Summary
The U.S. Department of State's Bureau of Global Health Security and Diplomacy (GHSD) issued an Annual Program Statement (APS) titled “Advancing Global Health” (DFOP0017890). This open competition seeks organizations to implement projects that operationalize the America First Global Health Strategy, complementing existing bilateral Memoranda of Understanding (MOUs) with partner governments. The program aims to save lives, strengthen health systems, enhance efficiency, foster self-reliance, and ensure U.S. investments benefit American safety and prosperity. Awards can range from $500,000 to $250 million, with total estimated funding up to $4.5 billion. Eligible applicants include U.S. and foreign for-profit, non-profit, higher education, public international organizations, and governmental institutions. Submissions are accepted as Statements of Interest (SOIs) in response to specific Addenda released quarterly, with rolling application deadlines. SOIs must describe the problem, proposed solution, anticipated outcomes, and partner roles. Full applications are by invitation only after an SOI review. Cost-sharing is not required but may be discussed during co-design. Specific funding restrictions apply, including prohibitions against supporting terrorist organizations, foreign security forces implicated in human rights violations, UNRWA, activities encouraging mass migration caravans, and the use of FASC-prohibited unmanned aircraft systems. Compliance with various federal regulations, including anti-discrimination and trafficking in persons laws, is mandatory. Applicants must have a Unique Entity Identifier (UEI) and SAM.gov registration for full applications, though not for initial SOI submission. Review criteria include program idea quality, organizational capacity, and ability to achieve objectives.
DFOP0017890 GHSD Advancing Global Health APS Child Protection Addendum.pdf
PDF304 KBApr 1, 2026
AI Summary
The U.S. Department of State's Bureau of Global Health Security and Diplomacy (GHSD) is launching an Annual Program Statement (APS) called "Advancing Global Health" (DFOP0017890). This initiative seeks organizations to implement projects aligning with the America First Global Health Strategy, focusing on bilateral Memoranda of Understanding (MOUs) with partner governments. The program aims to save lives, strengthen health systems, and foster self-reliance. Multiple awards, ranging from $500,000 to $250 million, will be granted over a period of up to five years, with total estimated funding up to $4.5 billion. Eligible applicants include U.S. and foreign for-profit enterprises, higher education institutions, faith-based organizations, Public International Organizations, and governmental institutions. The application process involves a two-phase submission: first, a Statement of Interest (SOI) in response to specific Addenda issued quarterly, followed by a full application for selected SOIs. While cost-sharing is not required, a Unique Entity Identifier (UEI) and SAM.gov registration are mandatory for full applications. The APS outlines detailed submission requirements, review criteria, funding restrictions, and post-award administrative and reporting requirements.
DFOP0017890 GHSD Advancing Global Health APS Outbreak Response Addendum.pdf
PDF215 KBApr 1, 2026
AI Summary
The Department of State's Bureau of Global Health Security and Diplomacy (GHSD) issued an Annual Program Statement (APS) titled "Advancing Global Health" (DFOP0017890). This open competition seeks organizations to implement projects that operationalize the America First Global Health Strategy, complementing bilateral Memoranda of Understanding (MOUs) with partner governments. Projects aim to save lives, strengthen health systems, enhance efficiency, foster self-reliance, and benefit U.S. safety and prosperity. Funding ranges from $500,000 to $250 million, with up to $4.5 billion available, supporting up to 100 awards over five years. Eligible applicants include U.S. and foreign for-profit, non-profit, higher education institutions, Public International Organizations, and governmental entities. The application process involves a two-phase submission: a Statement of Interest (SOI) in response to specific Addenda, followed by a full application for selected concepts. SOIs are reviewed quarterly, and selected applicants may engage in co-design with the Department of State. Rigorous eligibility, submission, and review criteria apply, including compliance with federal regulations and restrictions on funding activities that support terrorism, human rights violations, or mass migration. Successful applicants will receive a grant or cooperative agreement and must comply with post-award reporting requirements.
DFOP0017890 GHSD Advancing Global Health APS Amended as Highlighted 3-30-2026.pdf
PDF573 KBApr 1, 2026
AI Summary
The U.S. Department of State's Bureau of Global Health Security and Diplomacy (GHSD) issued an Annual Program Statement (APS) titled "Advancing Global Health," opportunity number DFOP0017890. This open competition invites eligible organizations to submit Statements of Interest (SOIs) to implement projects supporting the America First Global Health Strategy. The strategy aims to save lives, strengthen health systems, enhance efficiency, foster self-reliance, and ensure U.S. investments benefit American safety and prosperity. Awards can range from $500,000 to $250 million, with total estimated funding up to $4.5 billion over five years. SOIs are submitted in response to specific Addenda released quarterly, outlining GHSD priorities. Eligible applicants include U.S. and foreign private for-profit enterprises, higher education institutions, faith-based organizations, Public International Organizations, and governmental institutions. While cost-sharing is not required, a Unique Entity Identifier (UEI) and SAM.gov registration are necessary for full applications. The review process involves a merit review panel for SOIs, with selected applicants invited to submit full proposals.
DFOP0017890 Advancing Global Health APS Addendum 3 - Advancing Integrated and Sustainable Health Systems in the Philippines.pdf
PDF253 KBApr 17, 2026
AI Summary
The U.S. Department of State's Bureau of Global Health Security and Diplomacy (GHSD) issued an Annual Program Statement Addendum titled “Rapid Outbreak Response.” This addendum invites organizations to submit Statements of Interest (SOIs) for projects aimed at supporting countries in responding comprehensively to infectious disease outbreaks. The initiative aligns with Pillar One of the America First Global Health Strategy, focusing on rapid detection and containment of outbreaks to protect U.S. health and economy. Projects will prioritize swift activation, operational readiness, and flexibility, supporting immediate response actions across various technical and operational domains, including coordination, medical countermeasures, immunization, and surveillance. The goal is to enable rapid, effective, and coordinated outbreak response, reducing morbidity, mortality, and cross-border spread. The addendum outlines objectives such as rapid activation and surge response, early detection and containment, coordinated response, and system reinforcement. Key guiding principles include speed, country ownership, targeted resource use, risk-based decision-making, coordination, and sustainability. The deadline for questions is March 27, and SOIs are due by May 31. Up to 10 awards are anticipated, with total estimated funding up to $290 million, subject to availability, for projects lasting five years or less.
DFOP0017890 Advancing Global Health APS Round 1 Q&A 4-14-2026.pdf
PDF542 KBApr 17, 2026
AI Summary
The U.S. Department of State's Bureau of Global Health Security and Diplomacy (GHSD) invites organizations to submit Statements of Interest (SOI) for projects supporting rapid responses to infectious disease outbreaks. This addendum, titled "Rapid Outbreak Response" under the "Advancing Global Health" funding opportunity (DFOP0017890), seeks proposals to advance Pillar One of the America First Global Health Strategy: Making America Safer, with goals to detect outbreaks within seven days and contain them at their source. Up to 10 awards, totaling $290 million, are anticipated for projects focusing on speed, operational readiness, and flexibility, with a completion timeframe of five years or less. Key objectives include rapid activation and surge response, early detection and containment, coordinated response, and reinforcement of country systems. Projects must align with guiding principles such as speed, country ownership, targeted resource use, evidence-informed decision-making, coordination, and sustainability.
DFOP0017890 GHSD Advancing Global Health APS Addendum 1 - Child Protection.pdf
PDF304 KBApr 17, 2026
AI Summary
The U.S. Department of State's Bureau of Global Health Security and Diplomacy (GHSD) issued an addendum to its "Advancing Global Health" Annual Program Statement, inviting Statements of Interest (SOIs) for Rapid Outbreak Response (ROR) projects. This initiative, aligned with the America First Global Health Strategy, aims to support countries in rapidly responding to infectious disease outbreaks to contain them at their source and prevent pandemics. Projects should focus on immediate response actions during the earliest stages of an outbreak, prioritizing speed, operational readiness, and flexibility. Key objectives include rapid activation, early detection and containment, coordinated response, and reinforcement of country systems for sustained health security. Up to 10 awards, totaling an estimated $290 million, are anticipated for projects to be completed in five years or less. SOIs are due by May 31, 2024.
DFOP0017890 GHSD Advancing Global Health APS Addendum 2 - Outbreak Response.pdf
PDF215 KBApr 17, 2026
AI Summary
The U.S. Department of State's Bureau of Global Health Security and Diplomacy (GHSD) issued an Annual Program Statement Addendum for Rapid Outbreak Response (ROR). This initiative invites organizations to submit Statements of Interest (SOIs) for projects supporting countries in responding to infectious disease outbreaks. The goal is to advance rapid outbreak response in line with the America First Global Health Strategy, aiming to detect outbreaks within seven days and contain them at their source to protect Americans and the economy. The program seeks to enable timely, effective responses by supporting immediate actions during the earliest stages of an outbreak. Projects should prioritize speed, operational readiness, flexibility, and coordination, covering areas like incident management, medical countermeasures, immunization, and surveillance. The addendum anticipates up to 10 awards with an estimated total funding of up to $290 million, with projects to be completed in five years or less. Key objectives include rapid activation, early detection and containment, coordinated response, and system reinforcement. Guiding principles emphasize speed, country ownership, targeted resource use, evidence-informed decision-making, coordination, and sustainability.
DFOP0017890 GHSD Advancing Global Health APS Amended as Highlighted 4-14-2026.pdf
PDF392 KBApr 17, 2026
AI Summary
The U.S. Department of State's Bureau of Global Health Security and Diplomacy (GHSD) issued an Annual Program Statement Addendum for Rapid Outbreak Response (ROR), inviting organizations to submit Statements of Interest (SOI) for projects supporting countries in responding to infectious disease outbreaks. This initiative, part of the America First Global Health Strategy, aims to detect outbreaks within seven days and contain them at their source, safeguarding the U.S. economy and health. The program seeks to enable timely, effective responses during early outbreak stages, prioritizing speed, operational readiness, and flexibility. Projects should provide life-saving support across various technical and operational domains, reinforce critical country systems, and demonstrate operational feasibility in high-risk environments. Key objectives include rapid activation, early detection and containment, coordinated response, and system reinforcement. Up to 10 awards, totaling $290M, are anticipated, with SOIs due by May 31.

Related Grant Opportunities

Project Timeline

postedOriginal Opportunity PostedMar 5, 2026
amendedAmendment #1Mar 30, 2026
amendedLatest AmendmentApr 14, 2026
deadlineApplication DeadlineFeb 14, 2027

Funding Details

Award Ceiling
$250,000,000
Award Floor
$500,000
Est. Total Program Funding
$2,147,483,647
Expected Awards
100
No cost sharing required

Agency & Classification

Agency
Bureau of Global Health Security and Diplomacy(DOS-GHSD)
Funding Category
Health
Funding Instrument
Grant

CFDA Numbers

19.029

Official Sources