The National Institutes of Health (NIH) is preparing to publish a Notice of Funding Opportunity (NOFO) for the Cancer Intervention and Surveillance Modeling Network (CISNET) under the U01 cooperative agreement mechanism, which will not allow clinical trials. This initiative aims to leverage simulation modeling to enhance the evidence derived from clinical trials, epidemiologic studies, and surveillance data, thereby informing public health research and priorities throughout the cancer continuum. The opportunity is particularly relevant for small businesses with expertise in comparative simulation modeling methods for cancer control, as well as collaborative teams that integrate knowledge from decision modeling, statistics, health economics, epidemiology, computer science, medicine, and public health. Interested applicants should prepare for the application process, with the estimated synopsis posting date set for July 31, 2025, and the application deadline anticipated for November 7, 2025. For further inquiries, potential applicants can contact Dr. Natasha Stout at natasha.stout@nih.gov or by phone at 240-478-8909.