Impact of Immunotherapies on CNS Outcomes in People with HIV: Potential Benefits, Challenges and Risks
Grant Opportunity Analysis
The National Institute of Mental Health, within the National Institutes of Health, is planning a grant opportunity to study the impact of HIV immunotherapies on central nervous system outcomes in people with HIV. The work will support biphasic research that evaluates benefits, challenges, and risks, including how these therapies affect CNS HIV persistence, neurotoxicity, and neuroinflammation. The emphasis is on addressing CNS-specific barriers such as blood-brain barrier penetration, compartmentalized viral dynamics, and immune-mediated effects, and the opportunity will use the R21/R33 activity code. The estimated synopsis posting date is August 17, 2026, the estimated close date is October 22, 2026, and the program is expected to provide about $2 million across four awards, with questions directed to NIMH.DAR.inquiries@nih.gov.
Eligible Applicants
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;
Grant Documents
No documents available for this grant.