The Advanced Research Projects Agency – Energy (ARPA-E) is offering a funding opportunity titled "Nuclear Energy Waste Transmutation Optimized Now" (NEWTON) to support the research and development of innovative technologies for transmuting used nuclear fuel (UNF). The initiative aims to address the challenges associated with UNF management by reducing its volume, activity, and effective half-life through advanced particle generation and transmutation methods. This program is critical for enhancing the commercial viability of nuclear waste disposal solutions, shifting from long-term to intragenerational management of nuclear waste, thereby aligning with ARPA-E's mission to advance energy technologies and improve U.S. energy security. The total estimated funding for this opportunity is approximately $40 million, with individual awards ranging from $306,872 to $4.4 million. Interested applicants must register and submit a concept paper via ARPA-E eXCHANGE by August 16, 2024, and can direct inquiries to arpa-e-co@hq.doe.gov for further assistance.