The National Institutes of Health (NIH) is preparing to publish a Notice of Funding Opportunity (NOFO) for the Clinical Data Ecosystem for Genomics (CDEG), aimed at establishing a network to enhance the integration and sharing of genomic sequencing data among healthcare providers, labs, and patients. The initiative seeks to reduce barriers to clinical data sharing by creating a pilot ecosystem that demonstrates best practices, developing standardized APIs, and producing open-source clinical software applications that facilitate access to genomic data across various healthcare settings. This cooperative agreement is particularly relevant for small businesses with expertise in genomic medicine, data science, and health information exchange, and interested applicants are encouraged to begin forming collaborations in anticipation of the application process. For further inquiries, potential applicants can contact Jennifer Troyer at jennifer.troyer@nih.gov or by phone at 301-312-3276. The estimated synopsis post date is December 1, 2025, with applications expected to close by March 2, 2026, and awards anticipated by October 30, 2026.