NIH Directors Transformative Research Awards (R01 Clinical Trial Optional)
Grant Opportunity Analysis
The National Institutes of Health (NIH) is offering the NIH Directors Transformative Research Awards, a federal grant opportunity aimed at supporting innovative and groundbreaking research that has the potential to significantly alter scientific paradigms or improve clinical approaches. This program encourages applications from individual scientists or groups proposing bold research across various disciplines relevant to the NIH mission, with no preliminary data required for submission. Approximately $8 million is available for Fiscal Year 2026, targeting around seven awards, each with a maximum project period of five years, and key deadlines include an opening date on August 3, 2025, and a submission deadline of September 4, 2025. Interested applicants can find more information and guidelines at the NIH Grants website or contact NIH Grants Information at grantsinfo@nih.gov for inquiries.
Eligible Applicants
Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.