The Centers for Disease Control and Prevention (CDC) is offering a cooperative agreement to support life-saving HIV services and related health systems in Zambia, aligned with the President's Plan for AIDS Relief (PEPFAR). The initiative aims to enhance the capacity of the Zambian Ministry of Health to transition towards self-reliance while ensuring the sustainability of critical health services, including HIV treatment, laboratory support, and patient retention. This funding opportunity, with an estimated total of $120 million for fiscal year 2026, is open to unrestricted applicants, and interested parties should submit their applications electronically by February 17, 2026, to ensure consideration. For further inquiries, applicants can contact the grantor at pepfarfoas@cdc.gov.