The Department of Energy (DOE) Office of Science (SC) has issued Notice of Funding Opportunity (NOFO) DE-FOA-0003600 for FY 2026, seeking applications for its Financial Assistance Program. This annual open solicitation covers a wide range of research areas including Advanced Scientific Computing Research, Basic Energy Sciences, Biological and Environmental Research, Fusion Energy Sciences, High Energy Physics, Nuclear Physics, and Isotope R&D and Production. The NOFO is open until September 30, 2026, and anticipates approximately $500,000,000 in funding for 200 to 350 new awards, ranging from $5,000 to $5,000,000 each, with project periods of six months to five years. Eligible applicants include all entity types except certain lobbying nonprofit organizations, with specific guidelines for federally affiliated entities. Cost sharing is generally not required for basic research, and individual applicants are encouraged to demonstrate comprehensive skills and resources. Pre-applications are strongly encouraged, with specific deadlines and requirements for certain subprograms like Applied Mathematics and Computer Science, particularly for topics involving AI/ML and quantum computing. The NOFO emphasizes fundamental research over commercial activity and provides detailed contact information for various inquiries.