The National Institutes of Health (NIH) is offering a grant opportunity titled "Strategies to Improve Health Outcomes and Reduce Health Disparities in Rural Populations (R01 Clinical Trial Optional)." This funding initiative aims to support research focused on developing, adapting, and evaluating social determinants of health (SDOH) interventions specifically tailored for rural populations, addressing both adverse and positive SDOH impacts. The grant encourages pragmatic and implementation studies, including evaluations of the effects of local events or policies on health outcomes. Interested applicants, particularly small businesses, should note that the estimated synopsis will be posted on June 13, 2025, with a closing date for applications on August 12, 2025, and an anticipated award date of April 1, 2026. For further inquiries, applicants can contact Dr. Karen A. Kehl at karen.kehl@nih.gov or by phone at 301-594-8010.