The National Institutes of Health (NIH) is offering a grant opportunity titled "Strategies to Improve Health Outcomes and Reduce Health Disparities in Rural Populations (R01 Clinical Trial Optional)." This funding initiative aims to support research focused on developing, adapting, and evaluating social determinants of health (SDOH) interventions specifically tailored for rural populations, addressing both adverse and positive SDOH impacts. The grant encourages pragmatic and implementation studies, including evaluations of the effects of local events or policies on health outcomes. Interested applicants, particularly small businesses, should note that the estimated synopsis will be posted on June 13, 2025, with a closing date for applications on August 12, 2025, and an anticipated award date of April 1, 2026. For further inquiries, applicants can contact Dr. Karen A. Kehl at karen.kehl@nih.gov or by phone at 301-594-8010.

The purpose of this notice is to inform the research community that the National Institute of Nursing Research (NINR) intends to publish a notice of funding opportunity (NOFO), Strategies to Improve Health Outcomes and Reduce Health Disparities in Rural Populations (R01 Clinical Trial Optional), a re-issuance of RFA-NR-24-005.This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.This NOFO will utilize the R01 activity code. Details of the planned NOFO are provided below.Research Initiative DetailsThis funding opportunity will support research that seeks to develop, adapt, and/or evaluate social determinants of health (SDOH) interventions, or test strategies for the implementation of SDOH interventions already shown to be effective in rural populations. Research must address SDOH in the development, adaptation, implementation, or evaluation of interventions. Interventions or implementation strategies seeking to either mitigate or eliminate the impacts of adverse SDOH and/or bolster positive SDOH are of interest. Successful, evidence-based interventions may be adapted to specific rural communities and tested for acceptability and efficacy or effectiveness. Pragmatic and implementation studies are welcome, including hybrid effectiveness/implementation studies of adapted interventions or intervention bundles. Studies that include the evaluation of the impact of an event or policy (e.g., closing of local hospital, opening of a new employment center, change in internet access, new school consolidation) are welcome. Applications that are responsive to this NOFO will include an organizational-, community-, or population-level SDOH intervention. In addition, individual- or interpersonal-level interventions can be included in a multi-level intervention or intervention bundle.

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