AI-Enabled Discovery of Broad-Spectrum Small-Molecule Inhibitors for Filoviruses
Contract Opportunity Analysis
The U.S. Department of Health and Human Services’ ASPR, through BARDA market research, is seeking information on AI-enabled discovery of broad-spectrum small-molecule inhibitors for filoviruses. The opportunity focuses on organizations that can support AI-driven design, in vitro verification of hits, and early preclinical proof-of-concept for therapeutics targeting Ebola, Sudan, and Marburg viruses. The scope emphasizes advanced in silico methods, synthetic feasibility, ADME-Tox and safety considerations, and progression through lead selection and preclinical testing, with broad-spectrum activity across the listed filoviruses required. Responses are due by email to rrpv@ati.org by 1:00 p.m. EDT on June 17, 2026, and the submission should include a cover page and a technical response no longer than five pages.