Quadrupole-Orbitrap Hybrid Mass Spectrometer

The Human Foods Program (HFP) requires a quadrupole-orbitrap hybrid mass spectrometer to develop qualitative and quantitative proteomic research methods. This instrument will analyze complex protein mixtures in FDA-regulated foods and human cell samples exposed to toxic compounds, enabling detection and quantification of allergenic, toxic, transgenic, bacterial, viral, and emerging alternative proteins. It will also support the development of New Approach Methods (NAMs) to assess the toxicological effects of chemical constituents in botanical dietary supplements and human foods. The spectrometer must meet stringent specifications for acquisition speed (70 Hz), sensitivity (<1.5 fg), mass accuracy (<1 ppm), and resolving power (480,000 at m/z 200). Key components include an ion source, vacuum system, ion optics, mass analyzers, and an integrated data system with analysis software. The vendor must provide a new unit with a one-year service contract, personalized training, and an uninterruptable power supply. Delivery and installation are required by September 30, 2026, at the FDA/HFP facility in College Park, Maryland, with a twelve-month warranty.

The Food and Drug Administration (FDA) issued a Sources Sought Notice (HFP-2026-132840) to identify small businesses capable of providing a new quadrupole-orbitrap hybrid mass spectrometer system for its Human Foods Program in College Park, Maryland. This market research aims to inform the acquisition strategy for a system with advanced analytical capabilities for proteomics research, supporting the analysis of complex protein mixtures in FDA-regulated foods and human cell samples. The scope of work includes delivery, installation, integration, a one-year service warranty, preventive maintenance, training, and the provision of associated software and consumables. The system must meet stringent technical specifications, including high resolution, sensitivity, and rapid data acquisition, and be compatible with existing laboratory equipment. Interested businesses are requested to submit capability statements by April 27, 2026, detailing their experience with similar instrumentation, installation, training, and service agreements, as well as their technical capabilities and business size.

The Food and Drug Administration (FDA), Human Foods Program (HFP), is issuing a Request for Quotation (RFQ) HFP-2026-132840 for a newly manufactured Quadrupole-Orbitrap Hybrid Mass Spectrometer. This acquisition is set aside for small business concerns under NAICS Code 334516. The instrument will be used for qualitative and quantitative proteomic research in FDA-regulated foods and human cell samples, with specific technical requirements including acquisition speed of 70 Hz, sensitivity of less than 1.5 fg, mass accuracy of less than 1 ppm, and resolving power of 480,000 FWHM. The contractor must deliver and install the instrument at FDA/HFP in College Park, Maryland, by September 30, 2026. The contract includes a one-year service agreement, an uninterruptible power supply, a maintenance consumables kit, a factory warranty preventive maintenance visit, and on-site training. Trade-in services for existing instrumentation are also requested. Offers will be evaluated based on the Lowest Price Technically Acceptable (LPTA) method, and submissions are due as listed on SAM.gov. Invoices must be submitted electronically through the U.S. Department of Treasury's Invoice Processing Platform (IPP).

The Human Foods Program (HFP) requires a quadrupole-orbitrap hybrid mass spectrometer to develop qualitative and quantitative proteomic research methods. This advanced instrument will analyze complex protein mixtures in FDA-regulated foods and human cell samples exposed to toxic compounds, enabling the detection of allergenic, toxic, transgenic, bacterial, viral, and emerging alternative proteins. It will also support the development of New Approach Methods (NAMs) to assess the toxicological effects of chemical constituents in dietary supplements and foods. The spectrometer must meet stringent technical requirements for its ion source, ion optics, mass analyzers, and vacuum system, ensuring high acquisition speed, sensitivity, mass accuracy, and resolving power. The vendor must provide a newly manufactured unit, deliver and install it by September 30, 2026, demonstrate performance specifications, offer a one-year service contract, supply an uninterruptable power supply, and provide personalized, instructor-led training at the HFP location.