Phage Library Screening

This federal solicitation (No. 1232SA26Q0915), issued by the United States Department of Agriculture (USDA) Agricultural Research Service (ARS), seeks quotes for phage library screening services. The procurement is a total small business set-aside under NAICS code 541380, with an estimated size standard of $19 million. The primary objective is to acquire phage display library and library screening services to identify peptide sequences that bind to bovine and porcine receptors, supporting the National Bio and Agro-Defense Facility (NBAF) in Manhattan, Kansas. The requirement is split into two contract line items (CLINs): CLIN 0001 for three library screening services for one protein, and CLIN 0002 for up to six additional library screening services. The USDA intends to award a single, firm-fixed-price purchase order. Evaluation will be conducted using the Lowest Price Technically Acceptable (LPTA) source selection process. Quotes will be assessed based on price, technical acceptability (requiring a detailed, site-specific technical approach), and past performance. Proposals are due by July 13, 2026, at 1:00 PM CT, and must remain valid for 90 days. Questions regarding the solicitation must be directed to Contracting Officer Erin Riffey. The document incorporates standard federal commercial clauses, including specific USDA provisions addressing anti-discrimination, Diversity, Equity, and Inclusion (DEI) compliance, and strict limitations on unenforceable supplier terms.

This Statement of Work (SOW) outlines a procurement contract by the USDA-ARS Foreign Animal Disease Research Unit at the National Bio and Agro-Defense Facility (NBAF) for phage library screening services. The project's goal is to identify peptide sequences that bind to bovine and porcine receptors to assist in developing more effective vaccines against foreign animal diseases. The selected contractor must perform quality control on up to three mammalian-expressed, His-tagged proteins provided by the USDA, purchase two distinct phage display libraries for each protein, and immobilize the target proteins. The contractor will conduct three rounds of negative and positive selection, amplify recovered phages, and select at least 30 blue-plaque clones for ELISA affinity testing and sequencing. Key deliverables include 6 to 12 candidate peptide sequences (with corresponding amino acid and nucleotide data), raw sequencing data, and a minimum of 50,000 Next-Generation Sequencing (NGS) reads per protein per library. The project operates on a strict timeline, with milestones ranging from 12 to 49 days post-initiation. The USDA retains full ownership of all intellectual property discovered during the project, and the contractor must sign a non-disclosure agreement. Payment is structured as 50% upon order and the remaining 50% on Net 30 terms.

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