The Department of Defense (DOD) is seeking innovative solutions through the Small Business Innovation Research (SBIR) program for the development of hydrogel-based drug delivery products aimed at treating traumatic brain injury (TBI) in military settings. The objective is to create a biodegradable hydrogel system that can effectively seal open skull fractures or penetrating brain injuries while facilitating the controlled release of therapeutic agents to mitigate intracerebral hemorrhage, prevent infection, and reduce brain swelling. This initiative addresses a critical gap in prehospital care for TBI, particularly in austere environments where traditional medical interventions may not be feasible. Interested parties should note that the solicitation is currently closed, with the application due date having been June 12, 2024. For further details, applicants can refer to the DOD SBIR website at https://www.dodsbirsttr.mil/topics-app/.