The National Institutes of Health (NIH) intends to publish a Notice of Funding Opportunity (NOFO) for the Liver Cirrhosis Network: Clinical Research Centers (U01 Clinical Trial Required). This initiative aims to solicit applications for research focused on liver cirrhosis, specifically to complete enrollment in ongoing studies, including the Liver Cirrhosis Network Longitudinal Cohort Study and the RESCU clinical trial. The program is significant for advancing understanding and treatment of liver diseases, with an estimated total funding of $3,302,147 and an award ceiling of $330,214, anticipating approximately 10 awards. Interested applicants, particularly small businesses with expertise in liver disease research, are encouraged to prepare for application submission, with the estimated synopsis post date on July 11, 2025, and a closing date of August 15, 2025. For further inquiries, contact Edward Doo, MD, at dooe@niddk.nih.gov or call 301-451-4524.