The National Institutes of Health (NIH) is preparing to publish a Notice of Funding Opportunity (NOFO) focused on the role of HIV infection and chronic inflammation in clonal hematopoiesis (CH), particularly clonal hematopoiesis of indeterminate potential (CHIP). The initiative aims to investigate the mechanisms by which chronic inflammation and HIV-related factors contribute to CHIP, as well as its prevalence among individuals with HIV and other chronic conditions, with the ultimate goal of developing innovative diagnostic and therapeutic strategies for heart, lung, blood, and sleep (HLBS) health. While applications are not currently being solicited, potential applicants are encouraged to begin forming collaborations and project proposals in anticipation of the funding opportunity, which is expected to open in April 2026, with an estimated award date in October 2026. For further inquiries, interested parties can contact the Division of Blood Diseases and Resources at nhlbidbdrgrantresource@nhlbi.nih.gov.