The National Institutes of Health (NIH) is announcing a funding opportunity for the establishment of multidisciplinary Tuberculosis Research Units (TBRUs) through a grant program aimed at enhancing the understanding of Mycobacterium tuberculosis (Mtb) and its interactions with the host. This initiative seeks to foster collaborative research that characterizes the roles of bacterial and host heterogeneity in infection outcomes and disease progression, with a focus on identifying determinants relevant to Mtb establishment and dissemination. The total estimated program funding is $10 million, with approximately five awards expected, and interested applicants are encouraged to begin forming collaborations in anticipation of the Notice of Funding Opportunity (NOFO) expected to be published in September 2025. For further inquiries, potential applicants can contact Richard T. Robinson, Ph.D., at richard.robinson@nih.gov or by phone at 202-607-8565.